Tottenham's top scorer suffered an injury to the same ankle during a game against Sunderland in September, which kept him out of action for seven weeks.
Tottenham removed advertising hoardings from the away end at White Hart Lane before the match as a precaution and stewards separating supporters were wearing hard-hats. Although both managers said they had not heard the songs, the Tottenham substitute Kyle Walker appeared to acknowledge the tone of the chants by pointing angrily towards the Millwall fans after Son scored the first of his goals.
Son doesn't just allow Tottenham to press, he also helps take Pochettino's beloved pressing game to another level.
Kane, 23, has scored 24 goals this season, including eight in his past five games.
Dele Alli got himself on the scoresheet in the second half, while goal-shy striker Vincent Janssen came off the bench to grab his first from open play in a Spurs shirt.
Dier then challenged striking duo Vincent Janssen and Heung-Min Son to step up: "Apart from that it was great that Sonny got a hat-trick and Vincent scored".
Certainly, Kane's injury will be a pretty major concern for Tottenham, regardless of its duration, but the Lilywhites are more than covered when it comes to replacing the striker.
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They have the ability to find holes in any defensive system and score goals at will especially during big European matches . The angle was tough, and he had a lot to focus on with the keeper and defender right on top of him.
"He twisted his ankle, now we wait assess tomorrow and see what has happened", he is quoted as saying in the report.
"I thought Spurs were brilliant against Everton on Sunday and they have progressed from 13 of their last 14 FA Cup ties against lower league opposition - expect that to be 14 of 15 at the weekend".
The injury could also keep Kane out of England's forthcoming friendly against Germany and the World Cup qualifier against Lithuania in March.
"Obviously Harry is very important for us, he's a big part of this team in many ways", he said. "Now we need them".
"We've got a very good squad, we're on a good run, playing very well at the moment".
Three semi-finalists have been confirmed and the fourth will be as well on Monday night as Premier League leaders Chelsea host arch-rivals Manchester United in a epic FA Cup quarterfinal. "It's wrong in society, and it's wrong in football".