In addition to the Hilltoppers, host Kentucky and Belmont will also play first round games at Memorial Coliseum.
But what about the regular season?
ACC Tournament champion Duke is the favorite to win the NCAA Tournament according to several Las Vegas sportsbooks. If you are a betting man or woman though, the odds say UNC and Duke will square up for a fourth time in the national title game. It comes down to simple comparison.
In fact, one of Duke's best players is happy to be in the same region as a couple of the nation's top-five ranked teams. League schedules were imbalanced.
Wake Forest (19-13, 9-9 ACC) earned the No. 11 seed in the South region and will open against Kansas State (20-13, 8-10 Big 12) in Dayton Wednesday.
Four play-in games will round out the March Madness tournament bracket, with Mount St. Mary's vs.
"I think the kids are excited about the prospect of being in the Lexington Region", UK head coach Matthew Mitchell said.
With most of the top seeds holding pretty steady across the sport, there hasn't been much bracketology movement leading up to the selection show. Arizona (+900) went 4-0 SU and ATS in the Pac-12 Tournament and knocked off both UCLA (+1200) and OR (+2200) to claim the conference title.
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Two, with Duke's status as one of the most-hated teams in America, the Trojans - by default - will have more fans than ever by tipoff Friday.
Which leaves the last spot. The Blue Devils are led, coincidently, by guard Lexie Brown, who transferred from Maryland. They were designated the No. 3 seed in the Lexington, Ky. region where all they will have to overcome Notre Dame and No. 2 Stanford while avoiding being upset.
Arizona, meanwhile, I am excluding here.
Overall, North Carolina can not be upset with the draw it's been given in the NCAA tournament. The Bulldogs suffered a 79-71 home loss to the BYU Cougars late in the regular season and were otherwise flawless, but they may have to defeat the second-seeded Arizona Wildcats (30-4) a second time to get to the Final Four for the first time in school history.
That brings us to Kentucky. He's also excited that they're playing so close to home.
UCLA should be waiting for Kentucky (or Wichita State) in the round of 16 even though Cincinnati is a very solid team that should beat Wake Forest. The Hilltoppers won both the C-USA crowns this season.
"It's going to be a fast pace and really up and down", he said. North Carolina will fall to the #2 seed in the East most likely, opposite Villanova.