Djokovic grinds out second-round win over No. 32 Simon

Murray suffered a shock third-round loss to Spain s 15th seed Albert Ramos-Vinolas 2-6, 6-2, 7-5 in more than two and a half hours.

Albert Ramos-Vinolas fought back from 4-0 down in the final set to claim the scalp of top seed Murray, who went down 2-6 6-2 7-5 on the clay in the principality.

Murray was playing only his second match since returning from a five-week layoff after an elbow injury having been handed a first-round bye in the first big European claycourt tournament of the season.

Nine-time Monte Carlo champion Nadal did not come bearing gifts on Zverev's 20th birthday, racing to victory in a one-sided contest.

"It's going to be a completely different match-up to the one with Gilles".

The 22-year-old had a chance to lead 3-1 in the decider but Nadal held firm and ultimately proved just the stronger.

"He's a lefty as well so it's good I got some practice in". After breaking Murray's serve again, Ramos-Vinolas served out the match on his second match point.

It is a damaging defeat for the Scot as he attempts to play himself into form ahead of the French Open in June.

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The 10th-seeded Goffin had lost all previous five matches to Djokovic and looked to heading for another when the 12-time Grand Slam victor led 4-2 in the decider.

Djokovic last played on the ATP Tour more than a month ago - although he did emerge to lead a Serbian Davis Cup win this month - and sat out the Miami Open last month with an elbow injury.

"I'll speak to my team a little bit about that". I don't hit the ball as hard as a lot of the guys.

Defending champion Rafael Nadal registered a speedy victory over promising teenager Alexander Zverev, beating him 6-1 6-1 in one hour and eight minutes.

There were wins too in Monte Carlo for fifth seed Marin Cilic, who knocked out Tomas Berdych in straight sets, while number 11 seed Lucas Pouille secured his passage through to the quarter-finals after his French compatriot Adrian Mannarino retired in the first set.

Top-seeded Brit Andy Murray posted a 7-5, 7-5 triumph over Luxembourg's Gilles Muller, while third-seeded Stan Wawrinka of Switzerland required three sets to dispatch Jiri Vesely of the Czech Republic, 6-2, 4-6, 6-2.

The British No.3 had never faced Nadal previously and he struggled to cope with the intensity of the Spaniard's play in the opening set.