Piperine - The Secret Weapon for Anti-Inflammation

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P> At almost every restaurant across the west, ubiquitous salt and black pepper shakers sit ready to enhance any type of food .

Piperine does little by itself, but is specifically well-known and used because it inhibits specific enzymes that detoxify the body and slow the glucuronidation process [1]. [2].

Aside increasing absorption of certain compounds, black pepper has a promising safety profile, which makes it ideal for human consumption [3]. Also known as Black Pepper, Piper Nigrum, Piperaceae

Editors' Thoughts on Piperine

This seems relatively safe given that it is a major constituent of black pepper and people have been consuming it for ages. My only concern would be to use higher doses of piperine every single day. First off, to get a single dosage of piperine via black pepper, one might find it challenging.

Piperine used with curcumin to boost immune strength during certain periods of illness or a couple of times per day. Week sounds reasonable. Doing it daily might create some long-term enzymatic actions that are not always beneficial.

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If you are going to take curcumin or think you need to, piperine is a must. Mansal Denton, Nootropedia Editor

Benefits of Piperine

While curcumin is the most well-known benefactor from piperine, there are many others including vitamin C, vitamin B6, and EGCG (a major constituent of green tea extract).

Aside from Increasing the bioavailability of certain drugs, there are a smattering of other benefits as well. Namely, piperine is involved with neurotransmitters considered to be antidepressant including serotonin and dopamine [6]. Another 2008 study in Food and Chemical Toxicology suggested there were cognitive enhancement effects, which increased attention and reasoning skills [7].

Increasing the bioavailability of certain drugs is a major benefit of piperine, but it is not the only interaction. The main mechanism that makes piperine beneficial is blocking enzymatic and blocking processes of the liver [8]. This leads us to ...

Side Effects of Piperine

The side effects of piperine are inextricably linked to the benefits. The same mechanism that aids in the absorption of curcumin can cause elevated levels of other drugs that interact with the same enzymes.

While most of the side effects of piperine are related to other variables (ie: drugs) in your system, it is

Piperine Dosage

The piperine dosage you consumed will depend heavily on the extract you purchase. One popular extract is called BioPerine, which is a standardized method for 95% piperine. On the BioPerine website, they even make claims that their product can increase the absorption of CoQ10 by 31.8%, vitamin C by 52.3% And beta-carotene by 61.2%, but whether these are scientifically verified or not is unknown.

Piperine is an extract from black pepper and is thus found in many local food and grocery stores. You can buy piperine from any of these locations, but just make sure any purchase has the percentage extract so that you are aware what you are getting.

It may be a good idea to use a standardized extract of bioperine In order to buy piperine in the right dosage (and to make sure you have a safe extract). There are plenty of bioperine extract for sale on Amazon and we have selected a recommended vendor for you here.

Selected Community Experiences

"The CYP3A4-inhibition is usually irreversible, meaning that it is "knocked-out" until new CYP3A4 is produced; 3-12 hours. Also depends very much on the potency of the inhibition; Quercetin (yerba maté, citrus) having a weak inhibitory effect, piperine a lot more potent one . "[9]