Action of Bacopa monnieri to antagonize cisplatin-induced emesis in Suncus murinus (house musk shrew) - ScienceDirect

History | Bread and Roses Centennial
Workers were not able to build a permanent union structure at the Lawrence plant until the late 1930s. The strikers won a 15% increase granting the largest increase to workers with lower wages.

Bacopa monnieri (BM , family Scrophulariaceae) is used in several traditional systems of medicine for the management of epilepsy, depression, neuropathic pain, sleep disorders and Memory deficits. The present study investigated the potential of BM and methanol BM and BMN -butanol fractions -ButFr) to reduce chemotherapy-induced emesis in Suncus murinus (house musk shrew). Cisplatin (30 mg / kg, i.p.) reliably induced retching and / or vomiting over a 2 day period. BM -MetFr (10-40 mg / kg, sc) and -ButFr (5-20 mg / kg, sc) antagonized the retching and / or vomiting response by (P <0.05) and 78.9% (p <0.05), respectively, while the 5-HT3 receptor antagonist, palonosetron (0.5 mg / kg, Sc), reduced the response by ~71% (p <0.05). The free radical scavenger / antioxidant, N (2-mercaptopropionyl) -glycine (30-300 mg / kg, sc) reduced the retching and / or vomiting response occurring on day one non-significantly by 44 % (p > 0.05). In conclusion, the BM and BM have anti-emetic activity comparable with palonosetron and MPG. BM may be useful alone or in combination with other anti-emetic drugs for the treatment of chemotherapy-induced emesis in man.