Action of Bacopa monnieri to antagonize cisplatin-induced emesis in Suncus murinus (house musk shrew) - ScienceDirect

Originally the pathogene causing the gomosis of the pineapple was classified as Fusarium moliniforme sp. Later, more recently it was reclassified as Fusarium guttiforme Nirenberg & O'Donnell 1998.

Bacopa monnieri (BM , family Scrophulariaceae) is used in several traditional systems of medicine for the management of epilepsy, depression, neuropathic pain, sleep disorders and Memory deficits. The present study investigated the potential of BM and methanol BM and BMN -butanol fractions -ButFr) to reduce chemotherapy-induced emesis in Suncus murinus (house musk shrew). Cisplatin (30 mg / kg, i.p.) reliably induced retching and / or vomiting over a 2 day period. BM -MetFr (10-40 mg / kg, sc) and -ButFr (5-20 mg / kg, sc) antagonized the retching and / or vomiting response by (P <0.05) and 78.9% (p <0.05), respectively, while the 5-HT3 receptor antagonist, palonosetron (0.5 mg / kg, Sc), reduced the response by ~71% (p <0.05). The free radical scavenger / antioxidant, N (2-mercaptopropionyl) -glycine (30-300 mg / kg, sc) reduced the retching and / or vomiting response occurring on day one non-significantly by 44 % (p > 0.05). In conclusion, the BM and BM have anti-emetic activity comparable with palonosetron and MPG. BM may be useful alone or in combination with other anti-emetic drugs for the treatment of chemotherapy-induced emesis in man.